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Sara Zarate and Gauri Pandey, college students from the lab of Rahul Srinivasan, assistant teacher in the Department of Neuroscience & Speculative Therapeutics, are co-first authors of the research. Their findings are released in the Journal of Neurochemistry. There are approximately  cytisine reddit  dealing with Parkinson's illness, a neurodegenerative disorder that results in a variety of signs that can include problem walking, tremblings, shaking and others unassociated to movement.

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Currently, there is no cure for Parkinson's and no treatment that can stop or avoid the loss of these dopamine nerve cells that are needed for the body to move. About a decade ago, Srinivasan became thinking about trying to understand why smokers and individuals who consume tobacco chronically are at a lower risk for establishing Parkinson's disease.

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"But individuals actually do not understand why that is, due to the fact that tobacco and smoke consist of so many various chemicals. One of the chemicals certainly is nicotine, and that discusses the addicting residential or commercial properties of tobacco and cigarette smoke. So, I began to study the possible role of nicotine in this protective effect against Parkinson's disease." Given the fact that it is extremely challenging to conduct human and animal trials using nicotine due to serious side-effects, Srinivasan chose to evaluate cytisine as an option to nicotine.

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"What cytisine does is it binds to target receptors however doesn't trigger them as effectively as nicotine," Srinivasan stated. "It keeps the receptors 'inhabited' and 'chaperones' them to the surface of the neuron. Given that cytisine is a natural compound, is offered quite freely and is pretty low-cost, I decided to evaluate this idea of chaperoning in an animal design of the disease to see if it works." Throughout experiments, the team artificially caused Parkinson's disease in animal designs.

Then, the researchers carried out a series of behavioral experiments in order to see if there was any sort of protective result on the animal designs that were provided cytisine. Their findings revealed that there was a protective result both in regards to decreasing the Parkinsonian behaviors and also in regards to reducing the number of dopamine neurons lost.